Malgorzata Bogdan
Professor
Extending the modified Bayesian Information Criterion (mBIC) to dense markers and multiple interval mapping
Författare
Summary, in English
The modified version of Bayesian Information Criterion (mBIC) is a relatively simple model selection procedure that can be used when locating multiple interacting quantitative trait loci (QTL). Our earlier work demonstrated the statistical properties of mBIC for situations where the average genetic map interval is at least 5 cM. In this work mBIC is adapted to genome searches based on a dense map and, more importantly, to the situation where consecutive QTL and interactions are located by multiple interval mapping. Easy to use formulas for the extended mBIC are given. A simulation study, as well as the analysis of real data, confirm the good properties of the extended mBIC.
Publiceringsår
2008-12
Språk
Engelska
Sidor
1162-1169
Publikation/Tidskrift/Serie
Biometrics
Volym
64
Issue
4
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
INTERNATIONAL BIOMETRIC SOC,
Ämne
- Probability Theory and Statistics
Nyckelord
- Model selection criterion
- Multiple QTL
- QTL interaction
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0006-341X