Ulf Gerdtham
Professor
Economic Evaluation of Interventions for Screening of Dementia
Författare
Summary, in Swedish
Objective: The objective is to systematically review the literature on economic evaluations of screening interventions for early diagnosis of dementia disorders.
Methods: A systematic search of published economic evaluation studies in English was conducted using specified key words in relevant databased and websites. Data extracted included methods and empirical evidence (costs, effects, incremental cost-effectiveness ratio) and we assessed if the conclusions made in terms of cost-effectiveness were supported by the reported evidence. The included studies were also assessed for reporting quality using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist. Results: Fourteen studies were identified and broadly fell into two groups: screening without biomarkers and screening using biomarkers. There was a considerable heterogeneity in methodological approaches, target populations, study time frames, and perspectives as well as types of biomarkers used. The sensitivity and specificity of screening instruments are one of the important aspects in estimating the cost-effectiveness of the interventions. Cost- effectivness of non-biomarker based interventions can not be judged due to lack of information. The biomarkers based screening have the potential to be cost-effective but their effectiveness has to be established first.
Conclusion: More economic evaluations studies as well as good quality effectiveness studies are required in screening strategies before these can be implemented in the clinical practice. Key words: Dementia, Screening, early diagnostic, economic evaluation
Methods: A systematic search of published economic evaluation studies in English was conducted using specified key words in relevant databased and websites. Data extracted included methods and empirical evidence (costs, effects, incremental cost-effectiveness ratio) and we assessed if the conclusions made in terms of cost-effectiveness were supported by the reported evidence. The included studies were also assessed for reporting quality using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist. Results: Fourteen studies were identified and broadly fell into two groups: screening without biomarkers and screening using biomarkers. There was a considerable heterogeneity in methodological approaches, target populations, study time frames, and perspectives as well as types of biomarkers used. The sensitivity and specificity of screening instruments are one of the important aspects in estimating the cost-effectiveness of the interventions. Cost- effectivness of non-biomarker based interventions can not be judged due to lack of information. The biomarkers based screening have the potential to be cost-effective but their effectiveness has to be established first.
Conclusion: More economic evaluations studies as well as good quality effectiveness studies are required in screening strategies before these can be implemented in the clinical practice. Key words: Dementia, Screening, early diagnostic, economic evaluation
Avdelning/ar
- Hälsoekonomi
- Nationalekonomiska institutionen
- Centrum för ekonomisk demografi
- EpiHealth: Epidemiology for Health
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
- Klinisk minnesforskning
Publiceringsår
2018-09-04
Språk
Engelska
Publikation/Tidskrift/Serie
Working Papers
Issue
2018:20
Fulltext
Länkar
Dokumenttyp
Working paper
Ämne
- Economics
Nyckelord
- Dementia, Screening, early diagnostic, economic evaluation
- Dementia
- Screening
- Early diagnostic
- Economic evaluation
- H43
- I10
- I18
Status
Published
Forskningsgrupp
- Health Economics
- Clinical Memory Research